No Surgery Required To Knock Off A Decade


We often hear “60 is the new 40” or “40 is the new 20,”  but what does that really mean? The meaning is deeper than you may think. My interpretation of this common saying is that while someone may be 60-years-old according to the calendar, or what we call chronological age, their body actually functions and feels more like a 40-year-old. In other words, their biological age, or the age their cells are acting, is actually 40.

Calculating Chronological Age vs. Biological Age

Chronological age is how old you are according to the calendar. To calculate this, take today’s date, subtract your birthdate and, presto, you have your chronological age! In contrast, calculating your biological age takes a bit more testing since biological age is a measurement of how old your cells are acting. Now we are not referring to your behavior, or mood, but rather the specific age the cellular and biological functions of your body are performing. Clearly, logic tells us that having a younger biological age would be more beneficial, so how can it be measured? There are numerous ways to test your biological age. One of the most convenient is an at-home saliva-based test that evaluates the methylation patterns of your DNA. Multiple researchers accept the hypothesis that DNA methylation patterns are indications of aging and a good measure of the potential onset of chronic diseases that come from aging. Therefore, longevity scientists agree that attempts to directly influence DNA methylation could reset our DNAmAge (or biological age) leading to a healthier, more “youthful” cell metabolism.

Positive and Negative Influences on Biological Age

Now that we understand the importance of biological age, what are the factors that can cause it to increase or decrease? There are three main categories that can impact biological age: 

  • Genetics: This is your DNA, which acts as a roadmap defining how your cells operate and function. DNA includes all the genes you were born with and if DNA was all there was that would be the end of the story. However, the two next categories have an effect on your DNA or more specifically on how your DNA is expressed. This is called epigenetics. If DNA is the body’s computer hardware, epigenetics is the software program that allows the specific functions to be expressed and performed. The two main influencing factors are biological and environmental.
  • Biological: This could be an existing acute or chronic disease state or perhaps the body lacks one or more key metabolic components to maintain healthy cell function and balance. An example of a biological effect would be a deficiency in AKG (alpha-ketoglutarate), an endogenous metabolite in the body that is essential for every cell in the body to produce energy. More on this later!
  • Environmental: The last main category, you will recognize as lifestyle choices. I call it environmental. This includes: activity and stress levels; your diet (the foods you eat); smoking; excess sun or pollution exposure. Basically, all healthy or unhealthy choices can influence cellular aging. Your cells areprogrammed to divide, multiply and perform basic biological functions. The more cells divide, the older they get. In turn, cells eventually lose their ability to function properly. Cellular damage can also increase as cells age and are exposed to behavioral and environmental stresses like smoking, sedentary lifestyle, sun damage, poor diet and emotional stress, which all promote increased inflammation.

Decreasing Biological Age

Up until now, the only way to decrease biological age is through dramatic lifestyle changes. Since you cannot change your genetics or DNA you were born with, the only way known to keep cells young has been to avoid environmental factors that age cells such as excess sun, pollution exposure and smoking; and to maintain a healthy diet, intermittent fasting, in addition to regular exercise daily. In these studies, fasting and exercising proved to reduce biological age, but only by about two years, after more than one year of rigorous lifestyle changes. In other words, it is a lot of work, for a minimal return.

However, new discoveries are changing the way we can influence our biological age. A recent randomized retrospective study published in the journal Aging, shows that taking Rejuvant, a patent-pending, blend of calcium-AKG (CaAKG) for seven months decreased biological age by an average of eight years. It is noteworthy that participants in the study made no lifestyle changes!

How could simply taking two pills of the dietary supplement Rejuvant, daily, affect biological age so dramatically? One possible explanation centers on methylation of your DNA, which ties into your biological age. As we age, our DNA methylation patterns change. These changes can alter and turn off the way our genes are expressed. We mentioned that AKG is produced by your body, but as we age the amount of AKG tapers off. In fact, between the ages of 40 and 80, AKG levels can decrease 10-fold. This means your AKG levels may only be 10% what they were when you were younger. Compounding this issue is the fact that your body cannot get AKG from food. AKG supplementation is required to increase the levels in your body. However, it is likely that not all supplements are created equal. This is one of the reasons that I came on board as chief medical officer for Ponce de Leon Health, the makers of Rejuvant. What makes Rejuvant unique is that it is a timed-released form of CaAKG produced at a high potency and purity, specifically designed for increased absorption and effect. Through scientific research at the Buck Institute for Research on Aging, it was discovered that gender specific CaAKG formulations optimized outcomes. Following this research, Rejuvant men’s formula contains vitamin A plus CaAKG, while the women’s formula contains vitamin D plus CaAKG. 

At the end of the day it is not about how long we live, but how long we live well, which means maintaining an optimal state of health and well-being. To do this, take time to enjoy every moment of every day and strive to make positive meaningful lifestyle changes.

Dr. Francis Palmer

Dr. Francis Palmer is a world-renowned, board-certified facial plastic surgeon, and author of “What’s Your Number?” with more than three decades of practical experience in medicine. He consults as chief medical officer for Ponce de Leon Health, the makers of Rejuvant, a company dedicated to developing drug-free solutions scientifically proven to extend overall longevity, while simultaneously increasing healthspan and reducing biological age for better health. An honors graduate of San Diego State University, Palmer received his medical degree from the University of California – Irvine. Following his residency at USC-LA County Medical Center, he completed a fellowship with the American Academy of Facial Plastic and Reconstructive Surgery and is board certified in that specialty.

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